In this paper, a landslide prone area in Istanbul has been studied to show the seismic vulnerability of a proposed natural gas pipeline network. The area is located 9 km away to the north of the North Anatolian Fault Zone (NAFZ). NAFZ is seismically very active and a major earthquake is expected within the next 30 years. Due to the geotechnical characteristics of the formations and surface topography, landslides are another major problem in the area. In order to investigate the seismic vulnerability of a hypotetical natural gas pipeline system established in the region, parameters used were obtained from regional technical reports. The critical acceleration levels for the existing formations were taken from papers prepared for the region. The behavior of natural gas pipelines subject to permanent ground deformation and seismic wave propagation effects are examined and risks are highlighted.