Polymeric hollow fiber membrane oxygenators as artificial lungs: A review


Teber O. O., Altınay A. D., Mehrabani S. A. N., Şengür Taşdemir R., Zeytuncu Gökoğlu B., Genceli E. A., ...More

BIOCHEMICAL ENGINEERING JOURNAL, vol.180, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 180
  • Publication Date: 2022
  • Doi Number: 10.1016/j.bej.2022.108340
  • Journal Name: BIOCHEMICAL ENGINEERING JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chimica, Compendex, EMBASE, Food Science & Technology Abstracts, INSPEC, Veterinary Science Database
  • Keywords: Oxygenator, Membrane oxygenation, Artificial lung, Hollow fiber, Modification, GAS-EXCHANGE, POLYMETHYLPENTENE OXYGENATOR, MICROCHANNEL TECHNOLOGIES, PLATELET-ADHESION, BLOOD-FLOW, FABRICATION, SURFACE, DESIGN, MASS, BIOCOMPATIBILITY
  • Istanbul Technical University Affiliated: Yes

Abstract

The oxygenator is one of the most important components of respiratory support devices, which began as a heartlung machine for the treatment of heart diseases. Hollow fiber membranes have been widely used in oxygenators due to their outstanding performance in oxygen and carbon dioxide exchange with the blood. In this review, general information on the oxygenator historical evolutions is summarized. Then, the advantages and usage of hollow fiber membranes as oxygenators are explained. Modification strategies to prevent platelet adhesion, plasma leakage have been summarized. There has been some information given on design parameters for hollow fiber membrane oxygenators. In recent years, the rapid development of microchannel structures in oxygenators has been summarized. It is thought that this review will help the reader to find recent studies on the subject.