Synthesis and characterization of bile acid-based polymeric micelle as a drug carrier for doxorubicin

Altınkök Ç., Acik G., KARABULUT H. R. F., Ciftci M., TAŞDELEN M. A., DAĞ A.

POLYMERS FOR ADVANCED TECHNOLOGIES, vol.32, no.12, pp.4860-4868, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 12
  • Publication Date: 2021
  • Doi Number: 10.1002/pat.5478
  • Journal Name: POLYMERS FOR ADVANCED TECHNOLOGIES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, Aerospace Database, Applied Science & Technology Source, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, INSPEC, Metadex, Civil Engineering Abstracts
  • Page Numbers: pp.4860-4868
  • Keywords: amphiphilic, drug release, lithocholic acid, photopolymerization, CHOLIC-ACID, PHOTOINITIATED POLYMERIZATION, POLY(ETHYLENE GLYCOL), COPOLYMERS, AGGREGATION, TRANSPORT, RELEASE, BINDING, PH
  • Istanbul Technical University Affiliated: Yes

Abstract

In the present study, a polymeric micelle based on amphiphilic block copolymer, namely poly(methacrylated methyl lithocholate)-block-poly(oligoethylene glycol methacrylate) (PMML-b-POEGMA) bearing bile acid moiety is prepared via sequential photo-initiated free radical polymerizations, and its drug carrying capacity is investigated using doxorubicin hydrochloride (DOX) as a model drug. For this purpose, two-step procedure is applied in the presence of phenylbis (2,4,6-trimethylbenzoyl)phosphine oxide (BAPO) as bifunctional photo initiator. Based on spectroscopic and chromatographic analyses, the desired amphiphilic block copolymer (PMML-b-POEGMA) is successfully synthesized by wavelength-selective free radical photopolymerization under mild conditions. Finally, the DOX drug is loaded into the PMML-b-POEGMA micelles and then drug release behavior is investigated at two different pH (5.5 and 7.4) values. It is concluded from the results that PMML-b-POEGMA micelles may be used as an efficient nanocarrier to deliver conventional anti-cancer drugs for combination chemotherapy.