Synthesis and characterization of bile acid-based polymeric micelle as a drug carrier for doxorubicin


Altınkök Ç., Acik G., KARABULUT H. R. F., Ciftci M., TAŞDELEN M. A., DAĞ A.

POLYMERS FOR ADVANCED TECHNOLOGIES, cilt.32, sa.12, ss.4860-4868, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 12
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1002/pat.5478
  • Dergi Adı: POLYMERS FOR ADVANCED TECHNOLOGIES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, Aerospace Database, Applied Science & Technology Source, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, INSPEC, Metadex, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.4860-4868
  • Anahtar Kelimeler: amphiphilic, drug release, lithocholic acid, photopolymerization, CHOLIC-ACID, PHOTOINITIATED POLYMERIZATION, POLY(ETHYLENE GLYCOL), COPOLYMERS, AGGREGATION, TRANSPORT, RELEASE, BINDING, PH
  • İstanbul Teknik Üniversitesi Adresli: Evet

Özet

In the present study, a polymeric micelle based on amphiphilic block copolymer, namely poly(methacrylated methyl lithocholate)-block-poly(oligoethylene glycol methacrylate) (PMML-b-POEGMA) bearing bile acid moiety is prepared via sequential photo-initiated free radical polymerizations, and its drug carrying capacity is investigated using doxorubicin hydrochloride (DOX) as a model drug. For this purpose, two-step procedure is applied in the presence of phenylbis (2,4,6-trimethylbenzoyl)phosphine oxide (BAPO) as bifunctional photo initiator. Based on spectroscopic and chromatographic analyses, the desired amphiphilic block copolymer (PMML-b-POEGMA) is successfully synthesized by wavelength-selective free radical photopolymerization under mild conditions. Finally, the DOX drug is loaded into the PMML-b-POEGMA micelles and then drug release behavior is investigated at two different pH (5.5 and 7.4) values. It is concluded from the results that PMML-b-POEGMA micelles may be used as an efficient nanocarrier to deliver conventional anti-cancer drugs for combination chemotherapy.