The accelerated sea level rise and its resulting impacts on the highly populated coastal regions bearing significant economic value is one of the negative outcomes of climate change. In this study, the most vulnerable areas regarding sea level rise in Turkey are defined through CVI analysis, and the level of inundation is estimated from multi-mission satellite altimetry sea level anomaly, together with significant wave heights and the effects of tidal and meteorological forcing. Consequently, the maximum level of flooding that is expected to occur by 2100 reaches up to 6.7 m in Cukurova Delta which is one of the most vulnerable areas of the country, and GIS-based inundation mapping on the high resolution elevation model indicates that 69% of the area would be under the risk of flooding. Considering the probable sea level rise in Cukurova by the end of this century, immediate adaptive measures must be undertaken for the protection of the coastal zone. In addition, it will be of utmost importance to make an inventory of the vulnerable zones comprising coastal aquifers and ecosystems, and to introduce adaptive long-term strategies related to local coastal zone management plans.