Helicopters suffer from a number of problems raised from the high vibratory loads, noise generation, load capacity limitations, forward speed limitation etc. Especially unsteady aerodynamic conditions due to the different aerodynamic environment between advised and retreating side of the rotor cause most of these problems. Researchers study on passive and active methods to eliminate negative effects of aerodynamic loads. Nowadays, active methods such as Higher Harmonic Control (HHC), Individual Blade Control (IBC), Active Control of Structural Response (ACSR), Active Twist Blade (ATB), and Active Trailing-edge Flap (ATF) gain importance to vibration and noise reduction. In this paper, strain-induced blade twist control is studied integrated by Macro Fiber Composite (MFC) actuator. 3D model is presented to analyze the twisting of a morph and bimorph helicopter rotor blade comprising MFC actuator which is generally applied vibration suppression, shape control and health monitoring. The helicopter rotor blade is modeling with NACA23012 airfoil type and consists of D-spar made of unidirectional fiberglass, 45 Glass Fiber Reinforced Polymer (GFRP) and foam core. Two-way fluid-structure interaction (FSI) method is used to simulate loop between fluid flow and physical structure to enable the behavior of the complex system. To develop piezoelectric effects, thermal strain analogy based on the similarities between thermal and piezo strains. The optimization results are obtained to show the influence of different design parameters such as web length, spar circular fitting, MFC chord length on active twist control. Also, skin thickness, spar thickness, web thickness are used to optimization parameters to illustrate effects on torsion angle by applying response surface methodology. Selection of correct design parameters can then be determined based on this system results.