Fast-dissolving antibacterial nanofibers of cyclodextrin/antibiotic inclusion complexes for oral drug delivery

Topuz F., Kilic M. E., Durgun E., Szekely G.

JOURNAL OF COLLOID AND INTERFACE SCIENCE, vol.585, pp.184-194, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 585
  • Publication Date: 2021
  • Doi Number: 10.1016/j.jcis.2020.11.072
  • Journal Name: JOURNAL OF COLLOID AND INTERFACE SCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Applied Science & Technology Source, CAB Abstracts, Chemical Abstracts Core, Chimica, Compendex, EMBASE, INSPEC, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.184-194
  • Keywords: Electrospinning, Cyclodextrin, Inclusion complex (IC), Antibacterial nanofibers, Antibiotics, Oral drug delivery, TOTAL-ENERGY CALCULATIONS, FIBERS, WATER, ACID
  • Istanbul Technical University Affiliated: No

Abstract

Hypothesis: The widespread use of antibacterial electrospun nanofibers is mostly restricted due to their low loading capacity to carry antibiotics and the need to use toxic organic solvents to boost the antibiotic loading capacity. Nanofibers based on natural excipients, such as cyclodextrin (CD)-based nanofibers, can carry-larger amounts of antibiotics while achieving better stability via inclusion complexation.