In this article, the relationship between the ecological cycle and life, the built environment and life, the effects of the built environment on the public health are examined with the literature research technique and information about the interaction between ecology, built environment, skyscrapers and public health in various publications is presented. Istanbul was selected as a sample working area. The aim is to emphasize the relationship between high structures and the human health of these structures. The weakness of the study is that it does not investigate its effects by making field measurements. The strong direction of the study is that the effects of high buildings increasing day by day today are based on the literature studies of the effects on human health. (C) 2018 The Authors. Published by IASE.