In this study, GIS spatial analysis was performed in order to identify air pollution levels of Istanbul in relation to land use. Air quality parameters considered were Sulphur Dioxide (SO2) and Total Suspended Particulate matter (TSP). Spatial correlation among 17 monitoring stations was investigated using variogram analysis. The spatial and temporal analysis of air pollution problems was based on ambient air quality levels in the winter season. The GIS spatial analysis indicated that air pollution levels in the city were strongly related to land use type.