Temperature feedback control during laser-assisted tissue coagulation was investigated and demonstrated using the egg white model. Dynamics of photothermal denaturation during CO2 laser irradiation was observed by simultaneously controlling surface temperature and monitoring HeNe laser transmission of egg white samples. Once a quasi-constant surface temperature was established, transmission of egg white tended to decrease linearly with time. A first order rate process was observed. Our experiments demonstrated that thermal feedback can effectively control/limit photothermal damage.