Treatability of cefazolin antibiotic formulation effluent with O-3 and O-3/H2O2 processes

Iskender G., SEZER A., Arslan-Alaton I., Babuna F. F., Okay O. S.

WATER SCIENCE AND TECHNOLOGY, vol.55, no.10, pp.217-225, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 55 Issue: 10
  • Publication Date: 2007
  • Doi Number: 10.2166/wst.2007.325
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.217-225
  • Keywords: acute toxicity, activated sludge inhibition, advanced oxidation processes, antibiotic formulation effluents, chemical treatment, inert COD, pharmaceutical industry, BIOLOGICAL TREATABILITY, TOXICITY, BACTERIA, ALGAE
  • Istanbul Technical University Affiliated: Yes


The effect of applying ozonation and perozonation to antibiotic cefazolin-Na formulation effluents were investigated in this study. Twenty minutes of ozonation at a rate of 1,500 mg/L-h was observed to remove COD by 38%, whereas a COD removal efficiency of 40% was achieved via H2O2 enhanced ozonation (same conditions + 31.25 mM H2O2). Both of the pretreatment alternatives were monitored to elevate the BOD5/COD ratio from 0.01 to 0.08. The initially inert COD was reduced by 38% using ozonation and by 60% employing H2O2 enhanced ozonation. In terms of the lowest achievable effluent COD levels after bio-treatment, ozonation was observed to yield a residual COD of 205 mg L-1, while a residual COD of 135 mg L-1 was involved for perozonation. According to the results of acute toxicity on Phaedactylum tricornutum, ozonated and perozonated samples exhibited more toxicity than the untreated effluent after 4 days. The activated sludge inhibition test demonstrated that both of the pretreatment alternatives efficiently eliminated the inhibition of investigated formulation effluent.