Spectrophotometric determination of furosemide in pharmaceutical dosage forms using complex formation with Cu(II)


Gölcü A.

JOURNAL OF ANALYTICAL CHEMISTRY, vol.61, no.8, pp.748-754, 2006 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 61 Issue: 8
  • Publication Date: 2006
  • Doi Number: 10.1134/s1061934806080053
  • Title of Journal : JOURNAL OF ANALYTICAL CHEMISTRY
  • Page Numbers: pp.748-754

Abstract

dA simple, sensitive, and accurate spectrophotometric method has been developed for the assay of furosemide (FUR), which is based on the complexation of the drug with copper(II) at pH 3.2 using Mclivaine buffer solution to produce a green adduct. The latter has maximum absorbance at 790 nm and obeys Beer's law within the concentration range 5-30 mu g/mL. Regression analysis of the calibration data showed a good correlation coefficient (r = 0.9997) with minimum detection limit of 0.23 mu g/mL. The proposed procedure has been successfully applied to the determination of this drug in tablets. In addition, the spectral data and stability constant for the mononuclear copper(II) complex of furosemide (CuFUR2(MeOH)(2)) are reported.