This study reports on the testing of the hypothesis that there is a positive relationship between business strategy and innovativeness. Business strategy is defined here to include market focus strategy, technology development strategy, and operations priorities - including cost, quality, delivery / dependability, and flexibility. An empirical study is conducted based on data collected using a questionnaire developed. 184 manufacturing firms from different industries in the Northern Marmara region in Turkey participated in the study. Multivariate statistics techniques and structural equation modeling are employed. The results have been affirmative supporting the hypothesis. Market focus and technology development factors are found to mediate the effects of operations priorities on innovativeness. That market focus, technology development and cost efficiency have direct effects on innovativeness is another finding of managerial importance. © IFIP International Federation for Information Processing 2013.