Highly sensitive and cost-effective fluorescent turn-on sensors based on octamethylcalix[4]pyrrole receptor for the detection of fluoride anion

Amharar S., Aydoğan A.

DYES AND PIGMENTS, vol.197, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 197
  • Publication Date: 2022
  • Doi Number: 10.1016/j.dyepig.2021.109918
  • Journal Name: DYES AND PIGMENTS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Chimica, Communication Abstracts, Compendex, INSPEC, Metadex, Civil Engineering Abstracts
  • Keywords: Fluorescence indicator, Fluoride sensor, Displacement sensor, Calix[4]pyrrole, SELECTIVE RECOGNITION, WATER
  • Istanbul Technical University Affiliated: Yes


Cost-effective fluorescence turn-on indicator-displacement-assay (IDA) sensors based on octamethylcalix[4] pyrrole receptor and tetrabutylammonium salts of 4-methylumbelliferone and fluorescein indicators were developed for highly sensitive detection of fluoride anion. The IDA sensor assembly relies on the hydrogen bonding between calix[4]pyrrole and carboxylate units of indicators and further displacement replacement of receptors with target analyte. While all the sensors displayed rapid and selective sensitivity towards fluoride over the other anions, 4-methylumbelliferone based IDA system was also found to have a visual color change for the sensing of fluoride anion. The experimental results revealed that fluorescein-based IDA sensor could be used for the sensing of fluoride anion with a detection limit as low as 3.2 nM.