The preparation and biomedical applications of self-assembled two-dimensional sandalose gum supported polyvinyl alcohol/alginate bio-polymeric nanoparticles

KARAKUŞ S., Akkurt B., TÜZÜN E., Ozbas F.

POLYMER BULLETIN, cilt.80, sa.5, ss.5313-5332, 2023 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 80 Sayı: 5
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1007/s00289-022-04317-9
  • Dergi Adı: POLYMER BULLETIN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Chemical Abstracts Core, Chimica, Compendex, INSPEC
  • Sayfa Sayıları: ss.5313-5332
  • Anahtar Kelimeler: Polymeric nanoparticle, Sandalose gum, Surface characterization, Self-assembled two-dimensional, Nanostructure, ANTIMICROBIAL ACTIVITY, CHITOSAN NANOPARTICLES, STAPHYLOCOCCUS-AUREUS, PVA-ALGINATE, COMPOSITE, ANTIBACTERIAL, ANTIFUNGAL, DESIGN
  • İstanbul Teknik Üniversitesi Adresli: Evet

Özet

In this study, green self-assembled two-dimensional (2D) bio-preservatives were prepared for the sonosynthesis of sandalose gum-supported bio-polymeric nanoparticles (PNPs) with excellent biological activities. Polyvinyl alcohol (PVA), alginate (Alg), and sandalose gum (SG) were used to fabricate the green and low-cost bio-preservative. The prepared PVA/Alg/SG PNPs were confirmed using various characterization techniques such as SEM, HRTEM, XRD, FTIR, DLS, zeta potential, TGA, and DSC. According to the surface characterization results, the green self-assembled 2D PVA/Alg/SG PNPs had a spherical shape and particle diameters ranging from 10-50 nm. The thermal results showed that PVA/Alg/SG PNPs had good thermal stability. Furthermore, we investigated the antibacterial and antifungal activities of the self-assembled 2D PVA/Alg/SG PNPs as a safe bio-preservative against pathogenic microorganisms for use in biomedical applications. Consequently, our experimental results indicated a strong synergistic interaction between pathogenic microorganisms and the surface of the 2D nanostructure, resulting in the preservative efficacy of PNPs with a high performance.