The new generation drug candidate molecules: Spectral, electrochemical, DNA-binding and anticancer activity properties


Gölcü A. , Muslu H., Kilicaslan D., Cesme M., Eren O., Atas F., ...More

JOURNAL OF MOLECULAR STRUCTURE, vol.1119, pp.96-109, 2016 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 1119
  • Publication Date: 2016
  • Doi Number: 10.1016/j.molstruc.2016.03.078
  • Title of Journal : JOURNAL OF MOLECULAR STRUCTURE
  • Page Numbers: pp.96-109
  • Keywords: Metal based drugs, 5-Fluoracil, Electroanalysis, DNA binding, xCELLigence, METAL-COMPLEXES, SURFACE-MORPHOLOGY, 5-FLUOROURACIL, ACID

Abstract

The new generation drug candidate molecules [Cu(5-Fu)(2)Cl2H2O] (NGDCMI) and [Zn(5-Fu)(2)(CH3COO)(2)] (NGDCM2) were obtained from the reaction of copper(II) and zinc(II) salts with the anticancer drug 5-fluoracil (5-Fu). These compounds have been characterized by spectroscopic and analytical techniques. Thermal behavior of the compounds were also investigated. The electrochemical properties of the compounds have been investigated by cyclic voltammetry (CV) using glassy carbon electrode. The biological activity of the NGDCMI and NGDCM2 has been evaluated by examining their ability to bind to fish sperm double strand DNA (FSdsDNA) with UV spectroscopy. UV studies of the interaction of the 5-Fu and metal derivatives with FSdsDNA have shown that these compounds can bind to FSdsDNA. The binding constants of the compounds with FSdsDNA have also been calculated. Thermal decomposition of the compounds lead to the formation of CuO and ZnO as final products.