The advent of modem computers has greatly stimulated the development of general numerical algorithms and unstructured meshing approaches as credible design aids for simulating complex turbulent flows. However, the cell topology of the unstructured mesh determines the ultimate overall numerical accuracy of these simulations. The objective of this study is to better establish a quantitative assessment of the influence of cell topology in the computational mesh on the CFD results in order to help modelers to choose the most effective mesh type for their applications. Therefore, numerical experiments are performed here with different meshing approaches under similar numerical and mesh resolution conditions in order to lucid a physical picture of cell topology effect. It include two- and three-dimensional problems of engineering interest, for which either exact or benchmark numerical solutions are available or reliable experimental data exist, including line source in cross-flow, natural convection in thermal cavity, turbulent flow over backward facing step, and turbulent flow around 2D cylinder. The variety of the presented flow regimes allows us to draw several conclusions on the overall performance of the meshing methodologies.