Recent advances in oral delivery of bioactive molecules: Focus on prebiotic carbohydrates as vehicle matrices

Falsafi S. R., Bangar S. P., Chaudhary V., Hosseini E., Mokhtari Z., Can Karaça A., ...More

CARBOHYDRATE POLYMERS, vol.298, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 298
  • Publication Date: 2022
  • Doi Number: 10.1016/j.carbpol.2022.120074
  • Journal Name: CARBOHYDRATE POLYMERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Keywords: Prebiotics, Biopolymers, Delivery systems, Encapsulation, Bioactive agents, Targeted release, LACTOBACILLUS-RHAMNOSUS, ENZYMATIC PRODUCTION, KONJAC GLUCOMANNAN, PROTEIN ISOLATE, DRUG-DELIVERY, RICE BRAN, IN-VITRO, INULIN, STARCH, MICROPARTICLES
  • Istanbul Technical University Affiliated: Yes

Abstract

Controlled oral delivery of bioactive molecules remains a promising platform for the food and biomedical realm. Nonetheless, there are many bottlenecks to the efficient oral bioactive delivery that necessitates the development of advanced approaches. In recent years, prebiotic carbohydrates have drawn surging interest for targeted bioactive delivery due to their potential of multi-stimuli release mechanisms. Harnessing prebiotic-based vehicles confers novel possibilities for intact oral bioactive delivery, improving their bioavailability and efficacy. This critical review updates state of the art on progresses in oral delivery of natural active agents via prebiotic car-bohydrates. We offer the latest advances concerning prebiotic-based vehicles (i.e., pH/time-dependent systems, enzyme-sensitive polymers, and colonic microbiota-dependent vehicles), emphasizing their key attributes to attaining controlled/targeted bioactive delivery to the intended locus. Finally, we discuss safety considerations, challenges, and future perspectives toward advances in the field.