In this paper, the seismic resistance of unreinforced masonry (URM) cylindrical columns is investigated with an equivalent static analysis procedure. To this end, an existing numerical model developed for the stability analysis of masonry elements with rectangular cross-section is utilized and modified for the cylindrical columns. In the numerical model which takes into account the cracking of the sections and the second-order effects, the columns are divided ideally into sufficiently high number of elements, each having uniform curvature. The columns are modeled as prismatic cantilevers undergoing their own weights, eccentric vertical loads and distributed and concentrated static horizontal loads equivalent to the inertia actions. By considering two examples of columns, firstly a reference column and secondly a column from a real building, lateral seismic coefficient versus top drift level curves are obtained. On the basis of these curves, lateral load behavior of the columns is interpreted and maximum seismic load values which can be resisted by each column are determined. Implementing parametric analyses on the reference column, sensitivity of the seismic resistance to parameters such as column slenderness, magnitude and eccentricity of vertical top load, and the flexibility parameter is determined. The influence of some structural imperfections such as the deviation from vertical on the seismic resistance is also discussed in the paper.