Synthesis and Determination of Cerium(IV)-Reducing Antioxidant Capacity (CERAC) Assay of Some New Anthraquinones

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Bektaş N., ONUL N.

Acta Chimica Slovenica, vol.70, no.3, pp.440-448, 2023 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 70 Issue: 3
  • Publication Date: 2023
  • Doi Number: 10.17344/acsi.2023.8155
  • Journal Name: Acta Chimica Slovenica
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Central & Eastern European Academic Source (CEEAS), Chemical Abstracts Core, EMBASE, MEDLINE, Directory of Open Access Journals, DIALNET
  • Page Numbers: pp.440-448
  • Keywords: Anthraquinone, Antioxidant, Bioactive compounds
  • Istanbul Technical University Affiliated: Yes


Novel anthraquinone-based cyclic antioxidants containing amino, thio and oxo groups were synthesized and their antioxidant capacity was determined by using the cerium(IV)-reducing antioxidant capacity (CERAC) assay. 1H, 13C NMR, FTIR-spectroscopy and ESI (Electrospray Ionization) mass spectrometry were used for the characterization of anthraquinone derivatives exhibiting CERAC antioxidant capacity. This study is of great importance, because the antioxidant capacity of anthraquinone compounds was analyzed for the first time by the CERAC method and CERAC-Trolox equivalent antioxidant capacity (TEAC) values were higher than that for Trolox. It should also be noted that, since all synthesized anthraquinone derivatives have the potential to find applications in terms of their biological properties due to their sulfur and nitrogen content, they will make an important contribution to the literature.