Role of Dietary Antioxidants in Neurodegenerative Diseases: Where are We Standing?

Bakir S., Çatalkaya G., Ceylan F. D., Khan H., Guldiken B., Capanoglu E., ...More

CURRENT PHARMACEUTICAL DESIGN, vol.26, no.7, pp.714-729, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 26 Issue: 7
  • Publication Date: 2020
  • Doi Number: 10.2174/1381612826666200107143619
  • Journal Name: CURRENT PHARMACEUTICAL DESIGN
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.714-729
  • Keywords: Neurodegenerative diseases, dietary components, antioxidants, immune system, encephalopathy, amyotrophic lateral sclerosis, TRANSGENIC MOUSE MODEL, MULTIPLE-SCLEROSIS PATIENTS, POLYUNSATURATED FATTY-ACIDS, INDUCED HUNTINGTONS-DISEASE, REDUCING OXIDATIVE STRESS, PARKINSONS-DISEASE, ALZHEIMERS-DISEASE, EPIGALLOCATECHIN GALLATE, ALPHA-SYNUCLEIN, VITAMIN-E
  • Istanbul Technical University Affiliated: Yes

Abstract

This review presents the potential effects of dietary antioxidants on neurodegenerative diseases. The relationship between autoimmunity and antioxidants. and their preventive effect on neurodegenerative diseases are evaluated. The driven factors of neurodegeneration and the potential effects of natural antioxidants are summarized for Alzheimer's disease, Parkinson's disease, multiple sclerosis, spongiform encephalopathy, Huntington's disease, and amyotrophic lateral sclerosis. The effect of oxidative stress on neurodegenerative diseases and regulative effect of antioxidants on oxidative balance is discussed. This review provides beneficial information for the possible cure of neurodegenerative diseases with dietary intake of antioxidants.