In this study, we proposed a low-pass filter that dissipated very low power with dynamic threshold metal-oxide-semiconductor technique for Bluetooth low energy and biomedical applications of new portable Internet-of-Things devices. The operating frequency of the designed low-pass filter is between 750 and 1 MHz to meet the baseband requirements of Bluetooth and filter biomedical signals. The circuit uses two supplies to develop the performance of the circuit. The core circuit of the OTA-C filter operates on the sub-threshold region with +/- 0.2-V supply voltage, whereas the supply voltage of the biasing circuit is 0.6 V. The power consumption of the designed filter is 0.34 nW at 750 Hz and 376 nW at 1 MHz. The performance of the designed circuit is tested in Cadence environment with TSMC 0.18-mu m technology.