Hierarchical Self-Assembly of Histidine-Functionalized Peptide Amphiphiles into Supramolecular Chiral Nanostructures

Koc M. H., Ciftci G. C., Baday S., Castelletto V., Hamley I. W., GÜLER M. Ö.

LANGMUIR, cilt.33, sa.32, ss.7947-7956, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 32
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1021/acs.langmuir.7b01266
  • Dergi Adı: LANGMUIR
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.7947-7956
  • İstanbul Teknik Üniversitesi Adresli: Evet

Özet

Controlling the hierarchical organization of self-assembling peptide amphiphiles into supramolecular nanostructures opens up the possibility of developing biocompatible functional supramolecular materials for various applications. In this study, we show that the hierarchical self-assembly of histidine- (His-) functionalized PAs. containing D- or L-amino acids can be controlled by both solution pH and molecular chirality of the building blocks. An increase in solution pH resulted in the structural transition of the His-functionalized chiral PA assemblies from nanosheets to completely closed nanotubs through an enhanced hydrogen-bonding capacity and pi-pi stacking of imidazole ring. The effects of the stereochemistry and amino acid sequence of the PA backbone on the supramolecular organization were also analyzed by CD, TEM, SAXS, and molecular dynamics simulations. In addition, an investigation of chiral mixtures revealed the differences between the hydrogen-bonding capacities and noncovalent interactions of PAs with D- and L-amino acids.