Differential Pulse Voltammetric Determination of Montelukast in Tablets and Human Plasma by Using Chitosan Modified Carbon Paste Electrode


Yıldız G. , AYDOGMUS Z., Kauffmann J.

ELECTROANALYSIS, vol.25, no.7, pp.1796-1802, 2013 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 7
  • Publication Date: 2013
  • Doi Number: 10.1002/elan.201300077
  • Title of Journal : ELECTROANALYSIS
  • Page Numbers: pp.1796-1802

Abstract

Electrochemical reduction and determination of montelukast (MKS) was studied in methanol - 0.1M HCl solution (1:1, v/v) by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) at chitosan modified carbon paste electrode. The linear range was 1.70x10(-7)-1.83x10(-5)M for DPV analysis. Limit of detection (LOD) and limit of quantification (LOQ) were 5.32x10(-8)M and 1.61x10(-7)M, respectively. The developed method was successfully applied to the determination of MKS in tablets and spiked human plasma. The results obtained were in good agreement with those obtained using a reported spectrofluorimetric technique.