This work investigates the approximate solution for fourth-order multi-point boundary value problem represented by linear integro-differential equation involving nonlocal integral boundary conditions by using the reproducing kernel method (RKM). The investigated solution is represented in the form of a series with easily computable components in the reproducing kernel space. When the used algorithm for approximation is applied directly for the given original conditions, it can be very troublesome to compute the reproducing kernel of space. Therefore firstly, it is considered more appropriate conditions to be computed the kernel easily than original ones. Nextly, the original conditions are taken into account. Analysis is illustrated by a numerical example. The results demonstrate that the method is quite accurate and effective.