Computation of variance in compartment model parameter estimates from dynamic PET data

Kamasak M. E.

MEDICAL PHYSICS, vol.39, no.5, pp.2638-2648, 2012 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 5
  • Publication Date: 2012
  • Doi Number: 10.1118/1.3702456
  • Title of Journal : MEDICAL PHYSICS
  • Page Numbers: pp.2638-2648


Purpose: This paper investigates the validity of the analytical framework for variance ("analytical variance") in kinetic parameter and macroparameter estimations. Analytical variance is compared against the variance obtained from Monte Carlo simulations ("MC variance") for two different compartment models at different noise levels.