The synthesis and targeting of PPP-type copolymers to breast cancer cells: Multifunctional platforms for imaging and diagnosis


COLAK D. G., CIANGA I., Demirkol D. O., Kozgus O., MEDİNE E. İ., Sakarya S., ...More

JOURNAL OF MATERIALS CHEMISTRY, vol.22, no.18, pp.9293-9300, 2012 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 18
  • Publication Date: 2012
  • Doi Number: 10.1039/c2jm30692a
  • Journal Name: JOURNAL OF MATERIALS CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.9293-9300
  • Istanbul Technical University Affiliated: Yes

Abstract

Herein, we demonstrate the synthesis and application of water-soluble, biomolecule conjugated PPP copolymers bearing poly(ethylene glycol) (PEG) side chains as fluorescent probes for the in vitro imaging of cancer cells. The targeting of fluorescent polymers to breast cancer cells allows effective visualization and discrimination of MCF7 cells from human mammary epithelial cells. Furthermore, these materials are also suitable for efficient radiolabeling via I-125 which enables dual-modality holding the possibility of both radioactive and fluorescence imaging in cancer diagnosis applications.