The synthesis and targeting of PPP-type copolymers to breast cancer cells: Multifunctional platforms for imaging and diagnosis

COLAK D. G., CIANGA I., Demirkol D. O., Kozgus O., MEDİNE E. İ., Sakarya S., ...Daha Fazla

JOURNAL OF MATERIALS CHEMISTRY, cilt.22, sa.18, ss.9293-9300, 2012 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 18
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1039/c2jm30692a
  • Dergi Adı: JOURNAL OF MATERIALS CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.9293-9300
  • İstanbul Teknik Üniversitesi Adresli: Evet

Özet

Herein, we demonstrate the synthesis and application of water-soluble, biomolecule conjugated PPP copolymers bearing poly(ethylene glycol) (PEG) side chains as fluorescent probes for the in vitro imaging of cancer cells. The targeting of fluorescent polymers to breast cancer cells allows effective visualization and discrimination of MCF7 cells from human mammary epithelial cells. Furthermore, these materials are also suitable for efficient radiolabeling via I-125 which enables dual-modality holding the possibility of both radioactive and fluorescence imaging in cancer diagnosis applications.