Among biopolymers, polylactide (PLA) is considered as the most appropriate substitute for the petroleum-based polymers which are widely used in various commodity and engineering applications. PLA, however, also suffers from series of shortcomings such as slow crystallization rate and low melt strength which result in poor process ability, formability and foamability which substantially limit its production and usage. Recently, the use of biobased/biodegradable cellulose nanoparticles such as cellulose nanocrystals (CNC), cellulose nanofibers (CNF), and bacterial nanocellulose (BC) have been proposed to manufacture fully green PLA-based biocomposites while they could resolve some of the noted drawbacks of PIA. However, due to their high hydrophilicity and the presence of hydrogen bonding cellulose nanoparticles are not compatible with hydrophobic polymers. Therefore, the dispersion of these nanoparticles in thermoplastics still remains as the main challenge to process/develop their nanocomposites. This article reviews the studies conducted on these challenges of developing PLA cellulose-based nanocomposites including the difficulties of their processing and possible enhancements of their rheological, thermal, and mechanical properties. The investigations that have been conducted on PLA-CNC, PLA-CNF, and PLA-BC nanocomposites are separately discussed in this review article, while the studies on the development of PLA-nanocellulose blend nanocomposites and PLA-nanocellulose microcellular foams are also highlighted. (C) 2019 Elsevier B.V. All rights reserved.