Avocado-Soybean Unsaponifiables: A Panoply of Potentialities to Be Exploited

Salehi B., Rescigno A., Dettori T., Calina D., Docea A. O. , Singh L., ...More

BIOMOLECULES, vol.10, no.1, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 10 Issue: 1
  • Publication Date: 2020
  • Doi Number: 10.3390/biom10010130
  • Title of Journal : BIOMOLECULES
  • Keywords: avocado-soybean unsaponifiables, tocopherol, phytosterols, carothenes, osteoarthritis, scleroderma, menopause, HORMONE REPLACEMENT THERAPY, QUALITY-OF-LIFE, AVOCADO/SOYBEAN UNSAPONIFIABLES, DOUBLE-BLIND, DIETARY SOY, MENOPAUSAL SYMPTOMS, CONTROLLED-TRIAL, BONE LOSS, VITAMIN-E, IN-VITRO


Avocado and soybean unsaponifiables (ASU) constitute vegetable extracts made from fruits and seeds of avocado and soybean oil. Characterized by its potent anti-inflammatory effects, this ASU mixture is recommended to act as an adjuvant treatment for osteoarthritic pain and slow-acting symptomatic treatment of hip and knee osteoarthritis; autoimmune diseases; diffuse scleroderma and scleroderma-like states (e.g., morphea, sclerodactyly, scleroderma in bands). Besides, it was reported that it can improve the mood and quality of life of postmenopausal women in reducing menopause-related symptoms. This article aims to summarize the studies on biological effects of the avocado-soybean unsaponifiable, its chemical composition, pharmacotherapy as well as applications in autoimmune, osteoarticular and menopausal disorders. Finally, we will also discuss on its safety, toxicological and regulatory practices.