Water-insoluble polymer-free uniform nanofibers of peracetylated cyclodextrin by electrospinning

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Topuz F., Shaikh A. Y., Guler M. O., Uyar T.

JOURNAL OF MATERIALS SCIENCE, vol.55, no.25, pp.11752-11762, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 55 Issue: 25
  • Publication Date: 2020
  • Doi Number: 10.1007/s10853-020-04820-2
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Applied Science & Technology Source, Chimica, Communication Abstracts, Compendex, Computer & Applied Sciences, INSPEC, Metadex, Public Affairs Index, Civil Engineering Abstracts
  • Page Numbers: pp.11752-11762
  • Istanbul Technical University Affiliated: No


Hydrophobic cyclodextrin (CD) nanofibers were produced by the electrospinning of peracetylated beta-CD without requiring any polymer as a carrier matrix. Native beta-CD was peracetylated through the reaction with acetic anhydride, and the conversion of all hydroxyl groups into acetyl was confirmed by NMR, XPS, and TGA analyses. The peracetyl modification drastically boosted the thermal stability of the beta-CD molecules. The electrospinning of the peracetylated beta-CD from its highly concentrated solutions (180% (w/v)) in DMF led to bead-free nanofibers, while electrospinning at the concentrations of 140 and 160% (w/v) CDs resulted in beads and beaded nanofibers, respectively. The electrospinning process parameters such as applied voltage, flow rate, and tip-to-collector distances were systematically altered to produce a uniform nanofiber structure. The flow rate had the most drastic effect on the diameter and morphology of the resultant nanofibers: A threefold rise in the fiber diameter was observed with increasing the flow rate from 0.1 to 2 mL h(-1). Similarly, higher electrical field increased the fiber diameter due to higher mass flow, while boosting the tip-to-collector distance did not reveal any significant change on the fiber diameter. The stability of the peracetylated beta-CD nanofibers was observed in water for 24 h without any significant morphological change; however, the dissolution of the nanofiber mat was observed with a long-time exposure to water. We demonstrated production of hydrophobic uniform CD nanofibers without using any carrier polymer.