Surface topography can have a significant effect on ground motions during an earthquake. The shape and slope of the land can amplify or attenuate the ground motions, leading to variations in shaking intensity across a region. This study investigates the effects of surface topography on existing buildings based on a 10-story building located in Zeytinburnu district, Istanbul, Turkey. The lateral load resisting system of the building consists of shear walls and the structural design was completed according to Turkish Seismic Code 1997. Spatially varying simulated ground motions based on various large-scale physics-based ground motion simulations are applied to obtain seismic responses of the building for topo and flat cases where the topography effects of are considered and not, respectively. Three-dimensional nonlinear response history analyses are carried out in OpenSees. Structural response parameters such as peak story drift ratios, peak floor accelerations, and base shears are utilized to assess seismic response of the building under the influence of surface topography. Preliminary results of response history analyses show that responses are modestly higher (around 15–20%) when surface topography is taken into account.