Macroporous methacrylated hyaluronic acid cryogels of high mechanical strength and flow-dependent viscoelasticity

Tavşanlı B., Okay O.

CARBOHYDRATE POLYMERS, cilt.229, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 229
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.carbpol.2019.115458
  • Dergi Adı: CARBOHYDRATE POLYMERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chimica, Compendex, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • İstanbul Teknik Üniversitesi Adresli: Evet

Özet

We present here a new approach for the fabrication of macroporous hyaluronic acid (HA) cryogels with a tunable porous structure, flow-dependent viscoelasticity, and a high mechanical strength. They were synthesized from methacrylated HA in aqueous solutions at 18 C by free-radical mechanism using in situ prepared poly(N, Ndimethylacrylamide) (PDMAA) as a spacer. Both the porosity and the average diameter of the pores decrease from 99 to 90% and from 150 to 90 respectively, with increasing PDMAA content of the cryogels due to the simultaneous decrease in the amount of ice template during cryogelation. The cryogels also exhibit reversible strain-dependent apparent gel-to-sol transition due to the flowing-out and flowing-in water through the pores. This flow-dependent viscoelasticity is of great interest as it protects HA network from damage under large strain and hence acts as a self-defense mechanism.