Large number of vulnerable reinforced concrete (RC) buildings exists in earthquake prone areas. These low cost residential and/or commercial buildings, which are three to seven-stories high, usually do not receive essential engineering services during the construction phase. Finding cheap, easily applicable and occupant friendly retrofitting techniques are extremely important to reduce the seismic risk of these buildings. As an attempt to this, a particular type of high strength clay brick is studied to evaluate its potential for the structural retrofitting. A set of experiment was conducted to assess the important mechanical characteristics of the infill walls made from these bricks. Also the performance of two RC frames retrofitted with these walls, having different connection details between the wall and RC members was examined experimentally. The analytical nonlinear static analyses of these specimens have been performed using SeismoStruct to achieve some model parameters for representing the "infill wall model" in the program. Adaptive pushover and nonlinear time history analyses were conducted to investigate the performance of a six storey representative RC frame retrofitted with these walls. Evaluation of the results obtained in these analyses prove that this retrofitting technique introduces important strength and stiffness increments to the structure, regarding its seismic demands, which are similar to the results obtained from the experiments.