The Miocene magmatic intrusion in the Tavsanli zone of the Kutahya-Bolkardag Belt (KBB) in the northwestern region of Turkey is represented by the Egrigoz granitoids. This paper studies the petrology and geochemistry of hydrothermal alterations associated with the vein-type Cu-Pb-Zn mineralization hosted by this pluton, focusing on the determination of the mass gains and losses of chemical components, which reflect the chemical exchanges between the host rocks and hydrothermal fluids. Vein-type Cu-Pb-Zn mineralization is closely associated with intense hydrothermal alterations within the brecciation, quartz stockwork veining, and brittle fracture zones that are controlled by NW-SE trending faults cutting through the Egrigoz granitoids. Paragenetic relationships reveal three stages of mineralization: pre-ore, ore, and supergene. The ore mineralogy typically includes hypogene chalcopyrite, sphalerite, galena, and pyrite, with locally supergene covellite, malachite, and azurite. Wall-rock hypogene hydrothermal alterations include pervasive silicification, sulfidation, sericitization, and selective carbonatization and albitization. These are distributed in three main alteration zones (zone 1: silicified/iron carbonatized alterations +/- albite, zone 2: argillic-silicic alterations, and zone 3: phyllic alterations). Based on the gains and losses of mass and volume (calculated by the GEOISO-Windows (TM) program), zone 1 has a higher mass and volume gain than zones 2 and 3. Non-systematic zonal distributions of alterations are observed in which the silicic-carbonate alterations +/- albitization appeared in zone 1 in the center and the phyllic-argillic alterations appeared in zones 2 and 3, with an increase in base metals (Cu-Pb-Zn) in the zone from Cu, Cu-Pb, to Cu-Pb-Zn moving outwards.