Accurate and Sensitive Analytical Method for the Determination of Cyclanilide in Cotton and Cosmetic Pads at Trace Levels Using the Combination of Vortex Assisted Iron(II,III)/Reduced Graphene Oxide Nanocomposite Based Dispersive Solid Phase Extraction and High Performance Liquid Chromatography (HPLC)


ANALYTICAL LETTERS, vol.53, no.14, pp.2278-2291, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 53 Issue: 14
  • Publication Date: 2020
  • Doi Number: 10.1080/00032719.2020.1739062
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chimica, Communication Abstracts, Food Science & Technology Abstracts, Metadex, Veterinary Science Database, Civil Engineering Abstracts
  • Page Numbers: pp.2278-2291
  • Keywords: Cotton, cyclanilide, dispersive solid phase extraction, reduced graphene oxide nanocomposites, high-performance liquid chromatography (HPLC), SYNTHETIC COLORANTS, QUECHERS EXTRACTION, WATER, RESIDUES, MICROEXTRACTION, NANOPARTICLES, FABRICATION, FRUITS
  • Istanbul Technical University Affiliated: No


A novel, accurate and sensitive analytical method was developed to determine cyclanilide using vortex assisted Fe3O4/reduced graphene oxide nanocomposite based dispersive solid phase extraction by high performance liquid chromatography (HPLC). An iron (II,III)/reduced graphene oxide nanocomposite (Fe3O4/rGO) was employed to extract and separate cyclanilide from aqueous solution. After the optimization of HPLC system, important parameters for the extraction method including mass of Fe3O4/rGO, pH, volume of buffer solution, nature/volume of eluent solution and vortex period were examined to obtain the highest extraction yields. Under the optimum conditions, the enhancement in the detection power was found to be 35-fold by the developed method. The limits of detection and quantification of the proposed method were 2.6 and 8.7 ng g(-1), respectively. In order to characterize the accuracy and applicability of developed method, recovery studies were performed upon cotton and cosmetic pads. High percent recovery results between 90 and 104% were obtained for cotton and cosmetic pad samples. Therefore; this method may be easily applied to cotton samples with excellent precision and accuracy.